Action of Drug in Stereochemistry


The importance of stereochemistry in drug analysis is gaining greater attention in medical biology practice, and a basic knowledge of the subject will be necessary for clinicians to make informed decisions regarding the use of single-enantiomer drugs.   Chirality the most important point is that chiral drugs have 2 structurally similar forms that can behave very differently in biological systems due to their different shapes in 3-dimensional space. These 2 possible forms are termed as enantiomers and the 2 enantiomers of a given chiral drug should be considered 2 different drugs. In biological synthesis chiral drugs synthesises enantiomers of a chiral drug have identical physical and chemical properties in an achiral environment. In a chiral environment, one enantiomer may display different chemical and pharmacology of cancer drug behaviour than the other enantiomer. Because living systems are themselves chiral, each of the enantiomers of a chiral drug can behave very differently in vivo. In other words, the R-enantiomer of a drug will not necessarily behave the same way as the S-enantiomer of the same drug when taken by a patient


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